Ellagitannins target transcription factors and signalling pathways, resulting in apoptosis and inhibited proliferation of cancer cells.
One epigenetic mechanism is the upregulation of miRNAs involved in cell differentiation and proliferation.
References
- Bultman SJ.Interplay between diet, gut microbiota, epigenetic events, and colorectal cancer. Mol Nutr Food Res. 2017;61(1):1500902. Doi: 1002/mnfr.201500902 (Review)
- Hullar MA, Fu BC. Diet, the gut microbiome, and epigenetics.Cancer J. 2014;20(3):170. Doi: 10.1097/PPO.0000000000000053 (Review)