Epigallocatechin-3-gallate (EGCG) can modulate gene expression via two mechanisms:

  • altering DNA methylation patterns by the inhibition of DNMTs
  • influencing histone modifications by the inhibition of HATs33

Also, gallic acid and epigallocatechin, microbial products of EGCG metabolism, have also been found to inhibit HATs33.



  1. Bultman SJ.Interplay between diet, gut microbiota, epigenetic events, and colorectal cancer. Mol Nutr Food Res. 2017;61(1):1500902. Doi: 1002/mnfr.201500902 (Review)
  2. Hullar MA, Fu BC. Diet, the gut microbiome, and epigenetics.Cancer J. 2014;20(3):170. Doi: 10.1097/PPO.0000000000000053 (Review)